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Photo of Johan Karlsson

Johan Karlsson

Assistant Professor

Delivery is a major barrier to realize the transformative potential of RNA-based therapies. We're engineering innovative biomaterials that can spontaneously self-assemble with RNA molecules and form nanoparticles for precision delivery to enable treatments for unmet therapeutic needs.

To advance the field of nanomedicine, we are developing new nanoparticle design principles to facilitate nano-mediated delivery to targeted organs and highly specific delivery to cells involved in the diseases progression to enable precise therapies. We’re through our research establishing the relationship between chemical structures and activity of nanoparticles. One of our focuses is immunotherapy, since our immune system has the inherent capacity to provide protection from components/pathogens causing diseases. We’re engineering nanoparticles to program patients’ immune cells and cancer cells to induce signaling that would unleash the patient’s immune system full potential to recognize and fight cancer cells. Our research program is also pioneering technical advancements to enable new avenues for RNA-based therapies that would help patients having central nervous system (CNS) disorders.

Publications

2023

Elana Ben-Akiva, Johan Karlsson, Shayan Hemmati, Hongzhe Yu, Stephany Y. Tzeng, Drew M. Pardoll, Jordan J. Green (2023) Proceedings of the National Academy of Sciences of the United States of America, Vol. 120, Article e2301606120 (Article in journal)

2022

Elana Ben-Akiva, Johan Karlsson, Stephany Y. Tzeng, Hongzhe Yu, Jordan J. Green (2022) Systemic Drug Delivery Strategies, p. 31-62 (Chapter in book)

2021

Johan Karlsson, Stephany Y Tzeng, Shayan Hemmati, Kathryn M Luly, Olivia Choi, Yuan Rui, David R Wilson, Kristen L Kozielski, Alfredo Quiñones-Hinojosa, Jordan J Green (2021) Advanced Functional Materials, Vol. 31, Article 2009768 (Article in journal)
Johan Karlsson, Kathryn M Luly, Stephany Y Tzeng, Jordan J Green (2021) Advanced Drug Delivery Reviews, Vol. 179, Article 113999 (Article in journal)

2020

Johan Karlsson, Kelly R Rhodes, Jordan J Green, Stephany Y Tzeng (2020) Expert Opinion on Drug Delivery, Vol. 17, p. 1395-1410 (Article in journal)