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Photo of Christopher Sjöwall

Christopher Sjöwall

Professor

My long-term ambition is to contribute to increased understanding of underlying mechanisms for disease-onset, progress and quality of life in systemic inflammatory diseases, especially systemic lupus erythematosus.

Clinical and experimental rheumatology

The rheumatic diseases, such as rheumatoid arthritis (RA), spondylarthritis and systemic lupus erythematosus (SLE) belong to the endemic diseases, affecting more than 1 percent of the population of Sweden.

The immune system which protects us from bacterial and viral infections may in certain individuals with genetic susceptibility which are exposed to certain environmental factors loose its tolerance and attack endogenous tissues and organs. Knowledge on the etiology of rheumatic disease is increasing, and the number of treatment options for patients who suffer has risen dramatically in recent years.

My group is studying underlying mechanisms for rheumatic diseases, especially SLE, as well as biomarkers and autoantibodies in relation to diagnosis, treatment response and prognosis.


News

Publications

Selected publications

Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Karlsson J, Wetterö J, Potempa LA, Fernandez-Botran R, O'Neill Y, Wirestam L, Mobarrez F and Sjöwall C.

Journal of Autoimmunity, 2023-09-01, Volume 139, Article 103073, 

Graphical Abstract from the publication: Extracellular vesicles opsonized by monomeric C-reactive protein (CRP) are accessible as autoantigens in patients with systemic lupus erythematosus and associate with autoantibodies against CRP

Conformational state of C-reactive protein is critical for reducing immune complex-triggered type I interferon response: Implications for pathogenic mechanisms in autoimmune diseases imprinted by type I interferon gene dysregulation

Svanberg C, Enocsson H, Govender M, Martinsson K, Potempa LA, Rajab IM, Fernandez-Botran R, Wetterö J, Larsson M och Sjöwall C.

Graphical Abstract.

 

C-Reactive Protein Levels in Systemic Lupus Erythematosus Are Modulated by the Interferon Gene Signature and CRP Gene Polymorphism rs1205

Enocsson H, Gullstrand B, Eloranta M-L, Wetterö J, Leonard D, Rönnblom L, Bengtsson A och Sjöwall C.

Front. Immunol., 28 January 2021 | 

Figure 2 CRP levels among patients with and without detectable IL-6 levels (Z-axis) along with different CRP genotype (rs1205) and type I IFN gene signature (IGS) status (X-axis). Bars show median values.

Latest publications in DiVA

2025

Jesper Karlsson, Helena Enocsson, Hanna Duan, Suhana Ahmad, Daniel Appelgren, Alf Kastbom, Lina Wirestam, Christopher Sjöwall, Jonas Wetterö (2025) Autoimmunity, Vol. 58, Article 2579832 (Article in journal)
Juliana Imgenberg-Kreuz, Cecilia Fugmann, Anna-Maja Molin, Carin Backlin, Alina Johansson, Milica Vranic, Anna Nikkarinen, Per Eriksson, Christopher Sjöwall, Eva Baecklund, Gunnel Nordmark (2025) RMD Open, Vol. 11, Article e005897 (Article in journal)
Anna Glasin, Christina Svensson, Hanna Jonasson, Tomas Strömberg, Per Eriksson, Helene Zachrisson, Christopher Sjöwall (2025) Scandinavian Journal of Rheumatology (Article in journal)
Sarah Reid, Johanna K. Sandling, Pascal Pucholt, Ahmed Sayadi, Martina Frodlund, Karoline Lerang, Iva Gunnarsson, Andreas Jonsen, Ann-christine Syvanen, Oyvind Molberg, Solbritt Rantapaa-dahlqvist, Anna Rudin, Christopher Sjöwall, Elisabet Svenungsson, Anders A. Bengtsson, Lars Ronnblom, Dag Leonard (2025) Journal of Internal Medicine (Article in journal)
Lina Wirestam, Jesper Karlsson, Astrid Welin, Jhonatan Antonio Alvarez Gomez, Jonas Wetterö, Christopher Sjöwall, Helena Enocsson (2025) Clinical and Experimental Medicine (Testo stampato), Vol. 25, Article 317 (Article in journal)

Publications in PubMed and ORCiD

About me

CV

Christopher Sjöwall, associate Professor.Christopher Sjöwall, Senior Associate Professor. Photo credit Ulrik Svedin

Program teaching

  • Medical programme
  • Biomedical Laboratory Science Programme
  • Doctoral studies

Network

  • Member of the Swedish SLE network (since 2010)
  • Chairman of Working group that compose Guidelines for the medical treatment of SLE with an annual update on behalf of the Swedish Society for Rheumatology (since 2018)
  • Member of Employment board, Medical Faculty LiU (since 2021)

Organisation