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Pragmatic Research in Orthopedics - PRIO

Hip prosthesis in titanium with bone ingrowth. Photographer: Thor Balkhed

PRIO focuses on biological, mechanical and pharmacological aspects of fracture healing and implant osseointegration. Our translational approach aims to understand and explain complex clinical problems to improve decision making and thereby patient care.

Introduction

Bone is a unique tissue with the capacity to regenerate itself through true tissue regeneration by reactivation of embryonal processes. Implant fixation and healing of fractures are inherently related to each other on a biological level but often separated from each other in the minds of orthopedic surgeons. We are orthopedic surgeons with an interest in joint replacement and fracture treatment, anaesthesiologists, radiologists, biologists, movement scientists and others working together with national registries, the industry and academic collaborators around the world.

Hip prosthesis in titanium with bone ingrowth. Photo credit Thor BalkhedOur main focus is to improve the survival of first- time joint replacements through bone specific drugs and to improve outcome after complex joint revision surgeries with the use of morselized bonegraft, detailed pre-operative planning and evaluation of specific surgical techniques. We are interested in the pathomechanisms behind stress fractures, specifically atypical femoral fractures, the treatment and evaluation of healing and avoidance of early and late complications through implant choices guided through biomechanical understanding. Only then can we improve day-to-day practical decision making.

Our large research projects

ABOGRAFT logotype, a research project within the research group PRIO.

ABOGRAFT

Antibiotics blended into bonegraft used in hip revision surgery to prevent postoperative infection. A randomized controlled trial.
Read more here

BioFACTS

The BioFACTS study is a prospective multinational, multi-centre study involving patients with tibial fractures.

 

Research group

Principal researcher

Porträttfoto av Hans Peter Bögl.

Hans Peter Bögl
Studies healing aspects of atypical femoral fractures and the effect of fracture type and fracture fixation of femoral shaft fractures. Watch Hans Peter's author insight video .

Bild på Daphne Wezenberg.
Daphne Wezenberg

Bild på Lars Palm.
Lars Palm

Bild på Abraham Nilsson.
Abraham Nilsson
The aim of our research is to investigate whether biomarkers can be an objective tool for diagnosing acute compartment syndrome (ACS). We also investigate whether there is a difference in tissue composition among patients with the exertional form of compartment syndrome and whether ultrasound can be used as a tool for compartment pressure measurements. 

Bild på Rico Perlbach.

Rico Perlbach
Rico’s research is focused on specific surgical techniques, drugs and implant designs to improve outcome after acetabular revision and primary total hip replacement.

Bild på Jonathan Brandt.
Jonathan Brandt

Bild på Håkan Ledin.
Håkan Ledin
Studies the effects of tourniquet use and bone-specific drugs on implant fixation in primary total knee- and hip replacement.

Bild på Georg Zdolsek.
Georg Zdolsek
Investigates pathomechanisms that lead to the development of atypical femoral fractures, how to optimally treat and whether artificial intelligence improves the primary diagnosis of these fractures. 

Bild på Andreas Meunier.

Andreas Meunier

Rickard Sand
Rickard Sand
Studying atypical femur fractures with a focus on bisphosphonate naïve patients to understand how to prevent these fractures in at-risk populations.

Publications

Senaste publikationer i LiU DiVA

2025

Jörg Schilcher (2025) Acta Orthopaedica, Vol. 96, p. 584-586 (Article in journal)
Georg Zdolsek, Hans Peter Bogl, Rickard Sand, Aneta Liszka, Anna Fahlgren, Jörg Schilcher (2025) Acta Orthopaedica, Vol. 96, p. 421-428 (Article in journal)
Annette L. Adams, Margo Sidell, Alec D. Gilfillan, Denison S. Ryan, Jörg Schilcher, Dennis M. Black (2025) JBMR Plus, Vol. 9, Article ziaf071 (Article in journal)
Ronald Booij, Pauline de Klerk, Erik Tesselaar, Mischa Woisetschläger, Anne Brandts, Marielle Olsthoorn, Jakob van Oldenrijk, Koen Bos, Jörg Schilcher, Edwin H. G. Oei (2025) European Journal of Radiology Open, Vol. 14, Article 100646 (Article in journal)
Hans Peter Bögl, Jörg Schilcher (2025) Acta Radiologica (Article in journal)

Research projects of our collaborators

The TrAFFiC Study

The TrAFFiC Study is investigating risk factors and identifying causes of atypical femoral fractures to find ways to prevent it.

DUALITY

The purpose of the DUALITY study is to find out whether double cups reduce the risk of dislocation after a collum fracture.

HIPSTHER

HipSTHeR – Hip Screws or (Total) Hip Replacement. The HipSTHeR study is the first randomized study in orthopedics in the world.

FFT

Fragility Fracture Trial. Zoledronate in patients with fracture - a randomized double-blind study.

Collaborative partners

Map of the world where the countries Sweden, Denmark, USA, Australia and Germany are marked. In these countries, the research group PRIO has partners.

Map of collaboration

The marked countries on the world map illustrate the research group's partners (past and future projects).

CMIV (Center for Medical Image Science and Visualization (CMIV) - Linköping University

Experimental Orthopedics, Linköping University

, University of Gothenburg


News and LinkedIn

Contact

Jörg Schilcher

Professor
Lower extremity reconstruction unit
Department of orthopedic surgery and department of biomedical and clinical sciences
University Hospital Linköping and Linköping University
58185 Linköping
Phone: 0046101034291
Email: jorg.schilcher@liu.se

Organisation