Integrative Systems Biology (ISB)

Research group for Integrative systems biology (ISB) at Linköping University.

In the integrative systems biology group we aim towards being the world leading group in the unravelling of systems-level mechanistic insights, using inter-connected M4 models for decision support in pharma and P4 medicine – thereby making a positive change in society.

We do modelling in collaboration with a large number of experimental groups, focusing on different biological systems. In these projects, our collaborators serve as the biological experts, and we are the experts on the modelling. This means that our collaborators do not need to have extensive knowledge about modelling.

We are currently working on modelling of e.g. insulin signalling and lipolysis in adipocytes; nutrient fluxes on a whole-body scale; interpretation of fMRI signals in brain, and quantification of liver- and heart-diseases using MRI; modelling as an aid for improved drug development; and modelling to replace animal experiments.

In the systems biology group, we are constantly looking for new collaborations; be it students for internships, experimentalists for new projects or companies for making our insights of use for the public. Feel free to contact us if you want to know more!

Current research projects

Finished projects

Publications

2026

Henrik Podéus Derelöv, Christian Simonsson, Gerd Jakobsson, Robert Kronstrand, Elin Nyman, William Lövfors, Gunnar Cedersund (2026) Scientific Reports, Vol. 16, Article 9336 (Article in journal)
Rasmus Magnusson, Carl Soderberg, Liam Ward, Jenny Arpe, Fredrik Kugelberg, Albert Elmsjö, Henrik Green, Elin Nyman (2026) Nature Communications, Vol. 17, Article 1504 (Article in journal)

2025

Nilmini Wickramasinghe, Nalika Ulapane, Yuxin Zhang, Paul Jansons, Gunnar Cedersund, Ralph Maddison (2025) Sensors, Vol. 26, Article 82 (Article in journal)
Kajsa Tunedal, Tino Ebbers, Gunnar Cedersund (2025) Computers in Biology and Medicine, Vol. 188, Article 109878 (Article in journal)
Alejandro Garcia-Rudolph, Mark Andrew Wright, Claudia Teixido-Font, Rocio Sanchez-Carrion, Gunnar Cedersund, Eloy Opisso (2025) Topics in Stroke Rehabilitation (Article, review/survey)
Nicolas Sundqvist, Henrik Podéus, Sebastian Sten, Maria Engström, Salvador Dura-Bernal, Gunnar Cedersund (2025) Computers in Biology and Medicine, Vol. 197, Article 111014 (Article in journal)
Peter Thompson, Benjamin Jan Andersson, Nicolas Sundqvist, Gunnar Cedersund (2025) PLOS ONE, Vol. 20, Article e0327593 (Article in journal)
Wile Balkhed, Martin Bergram, Fredrik Iredahl, Markus Holmberg, Carl Edin, Carljohan Carlhäll, Tino Ebbers, Pontus Henriksson, Christian Simonsson, Karin Rådholm, Gunnar Cedersund, Mikael Forsgren, Olof Dahlqvist Leinhard, Cecilia Jönsson, Peter Lundberg, Stergios Kechagias, Nils Dahlström, Patrik Nasr, Mattias Ekstedt (2025) Journal of Internal Medicine, Vol. 298, p. 173-187 (Article in journal)
Alejandro Garcia-Rudolph, Sergiu Albu, Mark Andrew Wright, Maria del Mar Laya, Claudia Teixido, Eloy Opisso, Gunnar Cedersund, Montserrat Bernabeu (2025) Archives of Physical Medicine and Rehabilitation, Vol. 106, p. 729-737 (Article in journal)
Belén Casas Garcia, Kajsa Tunedal, Federica Viola, Gunnar Cedersund, Carljohan Carlhäll, Matts Karlsson, Tino Ebbers (2025) Scientific Reports, Vol. 15, Article 1352 (Article in journal)

Latest student publications

Christian Simonsson (2018)
Victor Viberg (2018)
Teodor Erngren (2017)

Research group

Organisation